CBD - Dossier

Cannabidiol (CBD) | The herbal super therapeutic agent

Tablet with hemp leaf, hemp seeds and the chemical formula for CBD

CBD - the herbal super therapeutic agent

Cannabidiol is fully in line with the trend. But what exactly is CBD? What effect does it have and can you administer it to your pet? Is CBD oil the same as hemp oil and why are CBD drops so popular? Answers to these questions and many more can be found in our large dossier on our favourite phytocannabinoid.

What is CBD?

Hand mit Handschuhe hält Hanfblatt in der Natur

Figure 1: Industrial hemp from which secondary plant substances such as CBD are extracted

CBD or cannabidiol is, besides THC, the most common secondary plant substance (or phytocannabinoid) of the female cannabis flower. This substance can account for up to 40% of the cannabinoid concentration [1] and is found in both cannabis and marijuana, but in completely different concentrations.

Unlike THC, CBD is not psychoactive [2], which facilitates the marketing and sale of the substance, but also its everyday use and research. Especially in everyday life, the substance is often used because of its therapeutic effect. Like all other cannabinoids, it is mainly found in the plant as an acid. For this reason it is also offered and sold in the form of oil (fatty acids).

Note: CBD is a non-psychoactive phytochemical that provides a high therapeutic benefit and is completely legal.

Why you exactly should try CBD

What does cannabidiol help against and is CBD legal ?

Woman doing yoga pose on island which is in mountain lake
Figure 2: Promoting the inner balance of body & mind is only one of many effects that the application of CBD can have

CBD is advertised, especially on the net, as a miracle weapon against just about every suffering. In fact, it works as a support against a range of everyday ailments and more serious diseases. Its anti-oxidant properties have been scientifically proven, making it particularly effective in reducing inflammation. It has also been shown to have a significant positive effect in the treatment of infantile epilepsy and multiple sclerosis [3].

Other positive experiences indicate a beneficial effect on sleep disorders, inner restlessness, anxiety and tension, menstrual problems, chronic pain, sore muscles and arthritis. However, more research is needed to confirm these effects scientifically. Fortunately, studies with CBD are not as problematic as those with the intoxicating cannabinoid THC, because the former is not psychotropic - it does not make you high - and is therefore safe for everyday use. However, for safe use, it is important to make sure that the THC content of all products is below 0.2%.

Note: CBD helps in many ways, both in mental and physical conditions. It is completely legal, because it does not have an intoxicating effect when used. CBD is therefore neither dangerous nor a drug.

How does CBD work ?

CBD interacts in a supportive way with the cannabinoid receptors CB1 and CB2, which occur naturally in the human body. These receptors normally mediate the functions that control the nerve cells in the brain as well as pain inhibition. In addition, increased activity reduces addictive behaviour and affects the appetite. The activation of the CB2 receptor is also associated with a positive effect on the course of Alzheimer's disease. A positive correlation with cancer is not scientifically known, but many cancer patients also report pain relief.

Note: Humans possess a natural, endogenous and very complex cannabinoid system, which is responsible for various functions such as pain relief, appetite and neuronal connections.

What is the best way to take CBD ?

CBD drops vs. CBD capsules
CBD capsules in container & CBD oil
Abbildung 3: CBD-Aromakapseln (links) & CBD-Aromaöl von Canutree (rechts)

The plant extract can be consumed in many different ways. Whether in the good old DIY manner, as butter or cocoa (more on this later), as oil or as capsules. There are hardly any limits to the way it can be taken. However, each way of consumption promises a different intensity or duration of effect. The most uncomplicated way is to consume the vegetable oil Sub Lingual. To be more precise, this means that you simply drop a few drops under your tongue and let the oil work before swallowing it. This way of taking promises the fastest absorption, as the oil is absorbed directly through the sensitive mucous membrane of the mouth.

The advantage of our capsules is not only the vegan processing, but also the delayed absorption, because they are completely decomposed only after the stomach. This promises a long-lasting effect and also has a beneficial effect on the entire digestive tract.

Note: Capsules have a more targeted effect, especially in the case of gastrointestinal complaints; the pure oil in the form of drops, absorbed sub lingually, has a somewhat faster effect.

Tips on dosage:
Hemp oil containing cannabidiol has a different effect on everyone. Depending on the dosage, it can have different effects. If you take just a little bit of it, it can have a positive effect on your well-being and even help against listlessness, but without further strong effects. A very high dosage can cause physical fatigue. We recommend increasing the dose in small steps to find out your personal optimum. CBD can be taken 1-3 times a day depending on the desired effect. The highest blood values are measured about 1-4 hours after ingestion [4].

Cannabidiol für dein Haustier ?

Hund & CBD-Kapseln in einer Hand
Katze und CBD-Öl, das in einer Hand gehalten wird

The phytocannabinoid acts as an anti-epileptic drug not only in humans, but also in animals [5]. In addition, it is thought to have similar positive effects on the animal body as in humans. However, a distinction must be made here between the species of animal and its weight. Studies have also found positive effects on osteoarthritis in dogs [6] without any noticeable side effects. The same study suggests that the plant substance should be administered a maximum of twice a day, at a dose of 2mg/kg. We recommend starting with very low doses, similar to those given to humans, and increasing them gradually. We also advise to stop cannabidiol again and again to avoid possible accumulation effects. There is no known risk but as our four-legged best friends cannot speak to us directly, we want to be as careful as possible with them. In general, however, no direct toxicity to (pets) is known when used in careful dosage. However, further research is needed to find out more about other effects.

Sources

[1] Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

10.1098/rstb.2011.0389

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531/

[2] Cannabis and Neuropsychiatric Disorders: An Updated Review

PMID: 31867704

https://pubmed.ncbi.nlm.nih.gov/31867704/

[3] The evidence for cannabidiol health benefits

https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476

[4] Alexandra Greb & Birgit Puschner (2018) Cannabinoid treats as adjunctive therapy for pets: gaps in our knowledge, Toxicology Communications, 2:1, 10-14, DOI: 10.1080/24734306.2018.1434470

[5] Emil Samara, Meir Bialer, Raphael Mechoulam Pharmacokinetics of Cannabidiol in Dogs, dmd.aspetjournals.org@content163469

[6] Lauri-Jo Gamble, Jordyn M. Boesch, Christopher W. Frye, Wayne S. Schwark, Sabine Mann, Lisa Wolfe, Holly Brown, Erin S. Berthelsen and Joseph J. Wakshlag* Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs, doi: 10.3389/fvets.2018.00165

Figure 1: Photo from Aphiwat chuangchoem from Pexels

Figure 2: Photo from Mikita Karasiou from Unsplash

Figure 3: Canutree

Figure 4:Canutree

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